Article
Interactions between genetic and epidemiological factors influencing mammographic density.
American journal of epidemiology - 7 May 2026
Suger Austin Hammermeister, Chen Hongjie, Haas Cameron B, Fan Shaoqi, Scott Christopher G, Bolla Manjeet K, Dennis Joe, Dunning Alison M, Michailidou Kyriaki, Wang Qin, Fasching Peter A, Haeberle Lothar, Stone Jennifer, Gago-Dominguez Manuela, Castelao Jose E, Murphy Rachel A, Aronson Kristan, Couch Fergus J, Yadav Siddhartha, Milne Roger L, Hopper John L, Norman Aaron, Eliassen A Heather, Tapper William J, Eccles Diana M, Evans D Gareth, Astley Susan, Hall Per, Czene Kamila, Pharoah Paul D P, Antoniou Antonis C, García-Closas Montserrat, Berrington Amy, Easton Douglas F, Gierach Gretchen L, Tamimi Rulla M, Vachon Celine M, Lindström Sara, Harrison Tabitha A
Abstract excerpt
Studies have identified genetic and epidemiologic factors associated with mammographic density (MD) phenotypes. However, MD-associated genetic variants only account for a small proportion of the total estimated heritability. Interrogating interactions between genetic and epidemiologic factors could potentially identify additional MD-associated loci, expand our understanding of the genetic basis of MD phenotypes,...
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