Mammographic breast density and breast cancer: evidence of a shared genetic basis.

doi:10.1158/0008-5472.CAN-11-3295

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Mammographic breast density and breast cancer: evidence of a shared genetic basis.

Cancer research - 15 Mar 2012

Varghese Jajini S, Thompson Deborah J, Michailidou Kyriaki, Lindström Sara, Turnbull Clare, Brown Judith, Leyland Jean, Warren Ruth M L, Luben Robert N, Loos Ruth J, Wareham Nicholas J, Rommens Johanna, Paterson Andrew D, Martin Lisa J, Vachon Celine M, Scott Christopher G, Atkinson Elizabeth J, Couch Fergus J, Apicella Carmel, Southey Melissa C, Stone Jennifer, Li Jingmei, Eriksson Louise, Czene Kamila, Boyd Norman F, Hall Per, Hopper John L, Tamimi Rulla M, Rahman Nazneen, Easton Douglas F

Abstract excerpt

Percent mammographic breast density (PMD) is a strong heritable risk factor for breast cancer. However, the pathways through which this risk is mediated are still unclear. To explore whether PMD and breast cancer have a shared genetic basis, we identified genetic variants most strongly associated with PMD in a published meta-analysis of five genome-wide association studies (GWAS) and used these to construct risk...

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PMID: 22266113
DOI: 10.1158/0008-5472.CAN-11-3295
PMCID: PMC3378688

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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