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Article

Genetic variation in peroxisome proliferator-activated receptor gamma, soy, and mammographic density in Singapore Chinese women.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Apr 2012

Lee Eunjung, Hsu Chris, Van den Berg David, Ursin Giske, Koh Woon-Puay, Yuan Jian-Min, Stram Daniel O, Yu Mimi C, Wu Anna H

Abstract excerpt

BACKGROUND: PPARγ is a transcription factor important for adipogenesis and adipocyte differentiation. Data from animal studies suggest that PPARγ may be involved in breast tumorigenesis, but results from epidemiologic studies on the association between PPARγ variation and breast cancer risk have been mixed. Recent data suggest that soy isoflavones can activate PPARγ. We investigated the interrelations of soy,...

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PMID: 22301832
DOI: 10.1158/1055-9965.EPI-11-1042
PMCID: PMC3408217

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