Cell-Specific Expression and Signaling of Glucocorticoid Receptor Isoforms Over Time in Critically Ill Patients with a Low Inflammatory Response

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Glucocorticoid (GC) signaling plays a crucial role in immune regulation during critical illness, but cell-specific responses remain poorly understood. While previous studies have predominantly examined GCR-α and GCR-β, the roles of alternative isoforms (GCR-γ, GCR-P) and downstream effectors (GILZ, DUSP1) across different immune cell populations in critical illn...

Topics

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• Adrenal Hormones and Disorders
• Cytokine Signaling Pathways and Interactions
• Electrolyte and hormonal disorders
• Estrogen and related hormone effects
• Hormonal Regulation and Hypertension
• Immune Response and Inflammation
• Intensive Care Unit Cognitive Disorders
• Stress Responses and Cortisol

Identifiers and source

Literature Corpus work

f23ddcda-bd70-5b57-90e5-86a2f24e2548

DOI

10.21203/rs.3.rs-6837042/v1