Article

Polymorphism in IFNAR contributes to glucocorticoid response and outcome in ARDS and COVID-19

2022-03-13

Abstract excerpt

The use of glucocorticoids has given contradictory results for treating acute respiratory distress syndrome (ARDS). Here we report a novel disease association of a SNP rs9984273, which is situated in the interferon alpha/beta receptor (IFNAR2) gene in an area corresponding to a binding motif of the glucocorticoid receptor (GR). The minor allele of SNP rs9984273 associates with higher IFNAR expression, lower IFN-ga...

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Literature Corpus work: 8a810e07-d268-5d4e-9d33-939816be10d8
DOI: 10.1101/2022.03.10.22272123

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