Article
Hyperactive Human Glucocorticoid Receptor Isoforms and their Implications for the Stress Response.
Shock (Augusta, Ga.) - 1 Mar 2015
Lasker Michael V, Leventhal Stacey M, Lim Debora, Green Tajia L, Tung Kelly, Cho Kiho, Greenhalgh David G
Abstract excerpt
Glucocorticoids are indispensable therapeutic agents in diseases of inflammation, but their effectiveness in treating advanced septic shock has been inconsistent. Our understanding of the mechanisms causing this variability to steroid therapy remains limited. Previous studies in our laboratory ha...
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