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Article

A high-content cellular senescence screen identifies candidate tumor suppressors, including EPHA3.

Cell cycle (Georgetown, Tex.) - 15 Feb 2013

Lahtela Jenni, Corson Laura B, Hemmes Annabrita, Brauer Matthew J, Koopal Sonja, Lee James, Hunsaker Thomas L, Jackson Peter K, Verschuren Emmy W

Abstract excerpt

Activation of a cellular senescence program is a common response to prolonged oncogene activation or tumor suppressor loss, providing a physiological mechanism for tumor suppression in premalignant cells. The link between senescence and tumor suppression supports the hypothesis that a loss-of-function screen measuring bona fide senescence marker activation should identify candidate tumor suppressors. Using a...

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Identifiers

PMID: 23324396
DOI: 10.4161/cc.23515
PMCID: PMC3594263

Genes

EPHA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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