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Article

Targeting p16INK4a-mediated cellular senescence as a therapeutic strategy for FLT3-ITD-driven acute myeloid leukemia.

Leukemia - 1 Nov 2025

Zheng Jiarui, Jin Linlin, Chen Yunlong, Duan Yongjuan, Zong Suyu, Wu Peng, Zhu Xiaofan, Yang Wenyu, Hu Tianyuan, Zhang Yingchi

Abstract excerpt

Cellular senescence serves as a critical tumor-suppressive mechanism across various cancer types, yet its role in FLT3-ITD-positive acute myeloid leukemia (AML) remains poorly understood. Through the analysis of multiple sequencing datasets, we identified that FLT3-ITD-positive patients with low p16INK4a expression have significantly worse prognoses. Consistent with these clinical findings, knockout of p16INK4a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40841767
DOI: 10.1038/s41375-025-02743-y

Genes

FLT3
E2F3
STAT5A

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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