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Article

Potassium Channel KCNA1 Modulates Oncogene-Induced Senescence and Transformation

18 Jun 2013

Abstract excerpt

Oncogene-induced senescence (OIS) constitutes a failsafe program that restricts tumor development. However, the mechanisms that link oncogenesis to senescence are not completely understood. We carried out a loss-of-function genetic screen that identified the potassium channel KCNA1 as a determinant of OIS escape that can license tumor growth. Oncogenic stress triggers an increase in KCNA1 expression and its...

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PMID: 23774215
DOI: 10.1158/0008-5472.can-12-3690

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