YPEL3, a p53-Regulated Gene that Induces Cellular Senescence

Abstract excerpt

Cellular senescence, the limited ability of cultured normal cells to divide, can result from cellular damage triggered through oncogene activation (premature senescence) or the loss of telomeres following successive rounds of DNA replication (replicative senescence). Although both processes require a functional p53 signaling pathway, relevant downstream p53 targets have been difficult to identify. Discovery of...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cancer-related Molecular Pathways
• Share to Telomeres, Telomerase, and Senescence
• Share to Ubiquitin and proteasome pathways