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Article

Conduction and block of inward rectifier K+ channels: predicted structure of a potent blocker of Kir2.1.

Biochemistry - 5 Feb 2013

Hilder Tamsyn A, Chung Shin-Ho

Abstract excerpt

Dysfunction of Kir2.1, thought to be the major component of inward currents, I(K1), in the heart, has been linked to various channelopathies, such as short Q-T syndrome. Unfortunately, currently no known blockers of Kir2.x channels exist. In contrast, Kir1.1b, predominantly expressed in the kidney, is potently blocked by an oxidation-resistant mutant of the honey bee toxin tertiapin (tertiapin-Q). Using various...

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PMID: 23320951
DOI: 10.1021/bi301498x

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