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Article

Conductance properties of the inwardly rectifying channel, Kir3.2: molecular and Brownian dynamics study.

Biochimica et biophysica acta - 1 Feb 2013

Hilder Tamsyn A, Chung Shin-Ho

Abstract excerpt

Using the recently unveiled crystal structure, and molecular and Brownian dynamics simulations, we elucidate several conductance properties of the inwardly rectifying potassium channel, Kir3.2, which is implicated in cardiac and neurological disorders. We show that the pore is closed by a hydrophobic gating mechanism similar to that observed in Kv1.2. Once open, potassium ions move into, but not out of, the cell....

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PMID: 23022491
DOI: 10.1016/j.bbamem.2012.09.022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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