Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

L chain allelic inclusion does not increase autoreactivity in lupus-prone New Zealand Black/New Zealand White mice.

Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 2013

Makdasi Efi, Eilat Dan

Abstract excerpt

L chain allelic inclusion has been proposed as a B cell tolerance mechanism in addition to clonal deletion, clonal anergy, and receptor editing. It is said to rescue autoreactive B cells from elimination by diluting out the self-reactive BCR through the expression of a second innocuous L chain. In autoimmune animals, such as lupus-prone mice, allelically included B cells could be activated and produce pathogenic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoantibodies
Share to B-Lymphocyte Subsets
Share to Gene Knock-In Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulin Light Chains

Share to Lupus Erythematosus, Systemic

Share to Mice, Inbred NZB

Share to Self Tolerance

Share to Up-Regulation

Source

Identifiers

PMID: 23319731
DOI: 10.4049/jimmunol.1202331

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

L chain allelic inclusion does not increase autoreactivity in lupus-prone New Zealand Black/New Zealand White mice.PMID 23319731Read ↗

Positive selection of natural poly-reactive B cells in the periphery occurs independent of heavy chain allelic inclusion.Semantic proximity Read ↗

Igkappa allelic inclusion is a consequence of receptor editing.Semantic proximity Read ↗

Autoreactivity and allelic inclusion in a B cell nuclear transfer mouse.Semantic proximity Read ↗

B cell development under the condition of allelic inclusion.Semantic proximity Read ↗

The lingering enigma of the allelic exclusion mechanism.Semantic proximity Read ↗

Allelic and isotypic light chain inclusion in peripheral B cells from anti-DNA antibody transgenic C57BL/6 and BALB/c mice.Semantic proximity Read ↗

Allelic exclusion of immunoglobulin genes: models and mechanisms.Semantic proximity Read ↗

Assembly of productive T cell receptor delta variable region genes exhibits allelic inclusion.Semantic proximity Read ↗

Lack of allelic exclusion permits autoreactive B cells to escape deletion.Semantic proximity Read ↗

Frequency and characterization of phenotypic Ig heavy chain allelically included IgM-expressing B cells in mice.Semantic proximity Read ↗

Editing disease-associated autoantibodies.Semantic proximity Read ↗

Receptor editing: an approach by autoreactive B cells to escape tolerance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.