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Article

RAS promotes tumorigenesis through genomic instability induced by imbalanced expression of Aurora-A and BRCA2 in midbody during cytokinesis.

International journal of cancer - 15 Jul 2013

Yang Gong, Mercado-Uribe Imelda, Multani Asha S, Sen Subrata, Shih Ie-Ming, Wong Kwong-Kwok, Gershenson David M, Liu Jinsong

Abstract excerpt

The oncogene RAS is known to induce genomic instability, leading to cancer development; the underlying mechanism, however, remains poorly understood. To better understand how RAS functions, we measured the activity of the functionally related genes Aurora-A and BRCA2 in ovarian cancer cell lines...

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Source

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Identifiers

PMID: 23319376
DOI: 10.1002/ijc.28032
PMCID: PMC3883442

Genes

BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23319376-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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RAS promotes tumorigenesis through genomic instability induced by imbalanced expression of Aurora-A and BRCA2 in midbody during cytokinesis.PMID 23319376Read ↗

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