The quiescent cellular state is Arf/p53-dependent and associated with H2AX downregulation and genome stability.

doi:10.3390/ijms13056492

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Article

The quiescent cellular state is Arf/p53-dependent and associated with H2AX downregulation and genome stability.

International journal of molecular sciences - 1 Jan 2012

Yoshioka Ken-Ichi, Atsumi Yuko, Fukuda Hirokazu, Masutani Mitsuko, Teraoka Hirobumi

Abstract excerpt

Cancer is a disease associated with genomic instability and mutations. Excluding some tumors with specific chromosomal translocations, most cancers that develop at an advanced age are characterized by either chromosomal or microsatellite instability. However, it is still unclear how genomic instability and mutations are generated during the process of cellular transformation and how the development of genomic...

Topics

Animals
Cell Transformation, Neoplastic
Cyclin-Dependent Kinase Inhibitor p16
Down-Regulation
Gene Expression Regulation, Neoplastic
Histones
Humans
Mutation
Neoplasms
Tetraploidy
Tumor Suppressor Protein p14ARF
Tumor Suppressor Protein p53

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Identifiers

PMID: 22754379
DOI: 10.3390/ijms13056492
PMCID: PMC3382772

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