Article
Next-generation sequencing of endoscopic biopsies identifies ARID1A as a tumor-suppressor gene in Barrett's esophagus.
Oncogene - 16 Jan 2014
Streppel M M, Lata S, DelaBastide M, Montgomery E A, Wang J S, Canto M I, Macgregor-Das A M, Pai S, Morsink F H M, Offerhaus G J, Antoniou E, Maitra A, McCombie W R
Abstract excerpt
The incidence of Barrett's esophagus (BE)-associated esophageal adenocarcinoma (EAC) is increasing. Next-generation sequencing (NGS) provides an unprecedented opportunity to uncover genomic alterations during BE pathogenesis and progression to EAC, but treatment-naive surgical specimens are scarce. The objective of this study was to establish the feasibility of using widely available endoscopic mucosal biopsies...
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