Article

Gammaherpesvirus infection licenses age-associated B cells for pathogenicity in MS and EAE

2021-07-22

Abstract excerpt

While age-associated B cells (ABCs) are known to expand and persist following viral infection and during autoimmunity, their interactions are yet to be studied together in these contexts. Epstein-Barr virus (EBV) infection has long been implicated in multiple sclerosis (MS), and it is not known whether ABCs could play a role in mediating viral contribution to autoimmunity. Here, we show that the circulating ABC po...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 13e49352-8f7a-5880-9470-0782996878b6
DOI: 10.1101/2021.07.22.453263

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Gammaherpesvirus infection licenses age-associated B cells for pathogenicity in MS and EAEDOI 10.1101/2021.07.22.453263Read

Gammaherpesvirus infection drives age-associated B cells toward pathogenicity in EAE and MSSemantic proximity Read

Latent gammaherpesvirus exacerbates arthritis through modification of age-associated B cells.Semantic proximity Read

Epstein–Barr virus and genetic risk variants as determinants of T-bet+ B cell-driven autoimmune diseasesSemantic proximity Read

Memory B Cells in Multiple Sclerosis: Emerging Players in Disease Pathogenesis.Semantic proximity Read

Early multiple sclerosis activity associated with TBX21+CD21loCXCR3+ B cell expansion resembling EBV-induced phenotypes.Semantic proximity Read

Age/autoimmunity-associated B cells in inflammatory arthritis: An emerging therapeutic targetSemantic proximity Read

An EBV-associated atypical B cell signature in clinically isolated syndrome is implicated in progression of multiple sclerosisSemantic proximity Read

The CD8 T Cell-Epstein-Barr Virus-B Cell Trialogue: A Central Issue in Multiple Sclerosis PathogenesisSemantic proximity Read

Latent virus infection upregulates CD40 expression facilitating enhanced autoimmunity in a model of multiple sclerosis.Semantic proximity Read

Epstein Barr Virus Exploits Genetic Susceptibility to Increase Multiple Sclerosis RiskSemantic proximity Read

Aging trajectories of memory CD8 <sup>+</sup> T cells differ by their antigen specificitySemantic proximity Read

Epstein-Barr virus and multiple sclerosis: lesson learned to develop better nonhuman primate models.Semantic proximity Read