Article

p53 Controls Murine Gammaherpesvirus Latency and Prevents Infection-Associated <i>IgH/c-Myc</i> Translocations

2020-08-02

Abstract excerpt

<h4>ABSTRACT</h4> Gammaherpesviruses (GHVs) establish life-long infections and cause cancer in humans and other animals. To facilitate chronic infection, GHV oncoproteins promote cellular proliferation and differentiation. Aberrant cell-cycle progression driven by viral oncogenes should trigger activation of tumor suppressor p53, unless p53 is functionally deactivated during GHV latency establishment. However, in...

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Literature Corpus work: 4b56d649-61e1-5cc9-a2f7-1f16537046a0
DOI: 10.1101/2020.08.02.233148

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