Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gammaherpesvirus infection drives age-associated B cells toward pathogenicity in EAE and MS

23 Nov 2022

Abstract excerpt

While age-associated B cells (ABCs) are known to expand and persist following viral infection and during autoimmunity, their interactions are yet to be studied together in these contexts. Here, we directly compared CD11c + T-bet + ABCs using models of Epstein-Barr virus (EBV), gammaherpesvirus 68 (γHV68), multiple sclerosis (MS), and experimental autoimmune encephalomyelitis (EAE), and found that each drives the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus and herpesvirus research
Share to Immune Cell Function and Interaction
Share to Viral-associated cancers and disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36427301
DOI: 10.1126/sciadv.ade6844

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gammaherpesvirus infection drives age-associated B cells toward pathogenicity in EAE and MSPMID 36427301Read ↗

Gammaherpesvirus infection licenses age-associated B cells for pathogenicity in MS and EAESemantic proximity Read ↗

Early multiple sclerosis activity associated with TBX21+CD21loCXCR3+ B cell expansion resembling EBV-induced phenotypes.Semantic proximity Read ↗

An EBV-associated atypical B cell signature in clinically isolated syndrome is implicated in progression of multiple sclerosisSemantic proximity Read ↗

Age/autoimmunity-associated B cells in inflammatory arthritis: An emerging therapeutic targetSemantic proximity Read ↗

Latent gammaherpesvirus exacerbates arthritis through modification of age-associated B cells.Semantic proximity Read ↗

Epstein–Barr virus and genetic risk variants as determinants of T-bet+ B cell-driven autoimmune diseasesSemantic proximity Read ↗

Memory B Cells in Multiple Sclerosis: Emerging Players in Disease Pathogenesis.Semantic proximity Read ↗

The CD8 T Cell-Epstein-Barr Virus-B Cell Trialogue: A Central Issue in Multiple Sclerosis PathogenesisSemantic proximity Read ↗

Aging trajectories of memory CD8 <sup>+</sup> T cells differ by their antigen specificitySemantic proximity Read ↗

Multiple Functions of B Cells in the Pathogenesis of Systemic Lupus ErythematosusSemantic proximity Read ↗

Latent virus infection upregulates CD40 expression facilitating enhanced autoimmunity in a model of multiple sclerosis.Semantic proximity Read ↗

Steady-state memory-phenotype conventional CD4+ T cells exacerbating autoimmune neuroinflammation in bystander manner via Bhlhe40/GM-CSF axisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.