Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ORF73 of murine herpesvirus-68 is critical for the establishment and maintenance of latency

26 Nov 2003

Abstract excerpt

In vitro studies have established that the latency-associated nuclear antigen encoded by human Kaposi's sarcoma-associated herpesvirus and the related ORF73 gene product of herpesvirus saimiri interact with virus origins of replication to facilitate maintenance of episomal DNA. Such a function implies a critical role for ORF73 in the establishment and maintenance of latency in vivo. To determine the role of ORF73...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus and herpesvirus research
Share to Herpesvirus Infections and Treatments
Share to Viral-associated cancers and disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 14645921
DOI: 10.1099/vir.0.19594-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ORF73 of murine herpesvirus-68 is critical for the establishment and maintenance of latencyPMID 14645921Read ↗

The Gammaherpesvirus 68 Latency-Associated Nuclear Antigen Homolog Is Critical for the Establishment of Splenic LatencySemantic proximity Read ↗

The M4 gene of gammaHV68 encodes a secreted glycoprotein and is required for the efficient establishment of splenic latency.Semantic proximity Read ↗

Murine gammaherpesvirus 68 ORF35 is required for efficient lytic replication and latency.Semantic proximity Read ↗

Modulation of B-cell tolerance by murine gammaherpesvirus 68 infection: requirement for Orf73 viral gene expression and follicular helper T cells.Semantic proximity Read ↗

The Murine Gammaherpesvirus 68 ORF27 Gene Product Contributes to Intercellular Viral SpreadSemantic proximity Read ↗

A gammaherpesvirus ubiquitin-specific protease is involved in the establishment of murine gammaherpesvirus 68 infection.Semantic proximity Read ↗

Conquering the Host: Determinants of Pathogenesis Learned from Murine Gammaherpesvirus 68Semantic proximity Read ↗

Generation of a Latency-Deficient Gammaherpesvirus That Is Protective against Secondary InfectionSemantic proximity Read ↗

Herpesvirus Saimiri Episomal Persistence Is Maintained via Interaction between Open Reading Frame 73 and the Cellular Chromosome-Associated Protein MeCP2Semantic proximity Read ↗

A gammaherpesviral internal repeat contributes to latency amplification.Semantic proximity Read ↗

Rta of Murine Gammaherpesvirus 68 Reactivates the Complete Lytic Cycle from LatencySemantic proximity Read ↗

Murine gammaherpesvirus 68 open reading frame 75c tegument protein induces the degradation of PML and is essential for production of infectious virus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.