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Article

The Nod-like receptor family member Naip5/Birc1e restricts Legionella pneumophila growth independently of caspase-1 activation.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2007

Lamkanfi Mohamed, Amer Amal, Kanneganti Thirumala-Devi, Muñoz-Planillo Raúl, Chen Grace, Vandenabeele Peter, Fortier Anne, Gros Philippe, Núñez Gabriel

Abstract excerpt

Similar to Ipaf and caspase-1, the Nod-like receptor protein Naip5 restricts intracellular proliferation of Legionella pneumophila, the causative agent of a severe form of pneumonia known as Legionnaires' disease. Thus, Naip5 has been suggested to regulate Legionella replication inside macrophages through the activation of caspase-1. In this study, we show that cytosolic delivery of recombinant flagellin...

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PMID: 17548639
DOI: 10.4049/jimmunol.178.12.8022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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