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Article

Virion stiffness regulates immature HIV-1 entry

10 Jan 2013

Abstract excerpt

BACKGROUND: Human immunodeficiency virus type 1 (HIV-1) undergoes a protease-mediated maturation process that is required for its infectivity. Little is known about how the physical properties of viral particles change during maturation and how these changes affect the viral lifecycle. Using Atomic Force Microscopy (AFM), we previously discovered that HIV undergoes a "stiffness switch", a dramatic reduction in...

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PMID: 23305456
DOI: 10.1186/1742-4690-10-4

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