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Article

Coupling of human immunodeficiency virus type 1 fusion to virion maturation: a novel role of the gp41 cytoplasmic tail.

Journal of virology - 1 Apr 2004

Wyma Donald J, Jiang Jiyang, Shi Jiong, Zhou Jing, Lineberger Janet E, Miller Michael D, Aiken Christopher

Abstract excerpt

Retrovirus particles are not infectious until they undergo proteolytic maturation to form a functional core. Here we report a link between human immunodeficiency virus type 1 (HIV-1) core maturation and the ability of the virus to fuse with target cells. Using a recently developed reporter assay of HIV-1 virus-cell fusion, we show that immature HIV-1 particles are 5- to 10-fold less active for fusion with target...

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Share to Cell Fusion
Share to gag Gene Products, Human Immunodeficiency Virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Products, gag

Share to HIV Antigens

Share to HIV Envelope Protein gp41

Share to Membrane Fusion

Share to Virion

Share to Virus Assembly

Source

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Identifiers

PMID: 15016865
DOI: 10.1128/jvi.78.7.3429-3435.2004
PMCID: PMC371074

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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