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Reverse transcription progression and genome length regulate HIV-1 core elasticity and disassembly

12 Jun 2025

Abstract excerpt

The structural and mechanical properties of the HIV-1 core are critical for successful infection, balancing stability for early replication and controlled disassembly for genome release. Recent studies have highlighted the role of core elasticity in nuclear entry, yet the molecular determinants regulating this property remain poorly understood. Here, atomic force microscopy (AFM) was used to investigate the...

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PMID: 40504880
DOI: 10.1371/journal.ppat.1013269

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