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Article

The host protein cyclophilin A restricts nuclear entry of HIV-1 mutants by reducing the elasticity of the viral capsid.

PLoS pathogens - 1 Jan 2026

Hong Jun, Deshpande Akshay, Thakare Yatish, Simonovsky Lora, Douglas AidanDarian W, Guinness Conall Mc, Rotem-Dai Noa, Kortyna Michelle L, Klarhof J Ole, Shi Jiong, James Leo C, Boecking Till, Francis Ashwanth C, Rousso Itay, Aiken Christopher

Abstract excerpt

Binding of the host protein cyclophilin A (CypA) to the viral capsid exerts multiple effects on HIV-1 infection, including enhancement of reverse transcription, stabilization of the capsid, and promotion of nuclear entry. CypA can also inhibit infection of selected HIV-1 mutants by a poorly understood mechanism. Using atomic force microscopy methods, we previously showed that HIV-1 cores are highly elastic and...

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Identifiers

PMID: 41610155
DOI: 10.1371/journal.ppat.1013910
PMCID: PMC12871957

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