Article
Gag-Gag Interactions Are Insufficient to Fully Stabilize and Order the Immature HIV Gag Lattice.
Viruses - 28 Sept 2021
Saha Ipsita, Preece Benjamin, Peterson Abby, Durden Haley, MacArthur Brian, Lowe Jake, Belnap David, Vershinin Michael, Saffarian Saveez
Abstract excerpt
Immature HIV virions harbor a lattice of Gag molecules with significant ordering in CA-NTD, CA-CTD and SP1 regions. This ordering plays a major role during HIV maturation. To test the condition in which the Gag lattice forms in vivo, we assembled virus like particles (VLPs) by expressing only HIV Gag in mammalian cells. Here we show that these VLPs incorporate a similar number of Gag molecules compared to...
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