HIV Nef amplifies mechanical heterogeneity to promote immune evasion

Abstract excerpt

Intracellular pathogens must evade cytotoxic immunity to establish persistent infection. Although immune escape is typically viewed through a biochemical lens, the ability of certain pathogens to alter the mechanical properties of infected cells suggests that biophysical mechanisms may also contribute to the process. Here, we show that a subset of CD4 + T cells infected with the human immunodeficiency virus (HIV)...

Topics

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• Cellular transport and secretion
• Cytomegalovirus and herpesvirus research
• Erythrocyte Function and Pathophysiology
• Herpesvirus Infections and Treatments
• HIV/AIDS drug development and treatment
• HIV Research and Treatment
• Immune Cell Function and Interaction
• RNA Research and Splicing

Identifiers and source

Literature Corpus work

ece4410c-dc23-5983-8256-6cddcfe6de3b

DOI

10.64898/2025.12.24.696400