Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased learning and brain long-term potentiation in aged mice lacking DNA polymerase μ.

PloS one - 1 Jan 2013

Lucas Daniel, Delgado-García José M, Escudero Beatriz, Albo Carmen, Aza Ana, Acín-Pérez Rebeca, Torres Yaima, Moreno Paz, Enríquez José Antonio, Samper Enrique, Blanco Luis, Fairén Alfonso, Bernad Antonio, Gruart Agnès

Abstract excerpt

A definitive consequence of the aging process is the progressive deterioration of higher cognitive functions. Defects in DNA repair mechanisms mostly result in accelerated aging and reduced brain function. DNA polymerase µ is a novel accessory partner for the non-homologous end-joining DNA repair pathway for double-strand breaks, and its deficiency causes reduced DNA repair. Using associative learning and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Behavior, Animal
Share to Conditioning, Classical

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA-Directed DNA Polymerase

Share to Hippocampus

Share to Learning

Share to Locomotion

Share to Long-Term Potentiation

Share to Oxidative Stress

Source

Open in PubMed Open full text

Identifiers

PMID: 23301049
DOI: 10.1371/journal.pone.0053243
PMCID: PMC3536760

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased learning and brain long-term potentiation in aged mice lacking DNA polymerase μ.PMID 23301049Read ↗

DNA polymerase β deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes.Semantic proximity Read ↗

Polμ deficiency increases resistance to oxidative damage and delays liver aging.Semantic proximity Read ↗

Accelerated Age-Related Cognitive Decline and Neurodegeneration, Caused by Deficient DNA RepairSemantic proximity Read ↗

Exercise-induced DNA damage response and memory formation in miceSemantic proximity Read ↗

The finger of an angel: memory return with epigenetic manipulation.Semantic proximity Read ↗

Mitochondrial ATP synthase 8 single-nucleotide polymorphism affects oxidative stress and survival of mice.Semantic proximity Read ↗

NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in miceSemantic proximity Read ↗

A tetracycline antibiotic minocycline prevents early aging phenotypes in mice heterozygous for RP58Semantic proximity Read ↗

Mitochondrial OPA1 deficiency causes reversible defects in adult neurogenesis-associated spatial memory in miceSemantic proximity Read ↗

Normal mitochondrial respiratory function is essential for spatial remote memory in mice.Semantic proximity Read ↗

Mutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation.Semantic proximity Read ↗

Modeling human age-associated increase in Gadd45γ expression leads to spatial recognition memory impairments in young adult miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.