Article

Exercise-induced DNA damage response and memory formation in mice

2025-09-28

Abstract excerpt

This study reveals that acute aerobic exercise enhances memory formation through a controlled DNA damage mechanism, offering crucial insights into Alzheimer’s disease (AD) prevention. This work challenges the traditional view that DNA damage is inherently harmful, demonstrating that minor, reversible DNA single-strand breaks (SSBs) induced by exercise serve as necessary primers for memory consolidation – a mechani...

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Literature Corpus work: b3f3023f-8a8b-597a-9c7d-5a3d3aea3b35
DOI: 10.1101/2025.09.26.678909

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