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NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in mice

2 Dec 2021

Abstract excerpt

Abstract Oxidative DNA damage in the brain has been implicated in neurodegeneration and cognitive decline. DNA glycosylases initiate base excision repair (BER), the main pathway for oxidative DNA base lesion repair. NEIL1 and NEIL3 DNA glycosylases affect cognition in mice, while the role of NEIL2 remains unclear. Here, we investigate the impact of NEIL2 and its potential overlap with NEIL1 on behavior in...

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PMID: 34857879
DOI: 10.1038/s42003-021-02864-x

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