Article
Mutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation.
Neuron - 1 Oct 1998
Jiang Y H, Armstrong D, Albrecht U, Atkins C M, Noebels J L, Eichele G, Sweatt J D, Beaudet A L
Abstract excerpt
The E6-AP ubiquitin ligase (human/mouse gene UBE3A/Ube3a) promotes the degradation of p53 in association with papilloma E6 protein, and maternal deficiency causes human Angelman syndrome (AS). Ube3a is imprinted with silencing of the paternal allele in hippocampus and cerebellum in mice. We found...
Topics
- Acoustic Stimulation
- Animals
- Association Learning
- Brain
- Cytoplasm
- Disease Models, Animal
- Learning Disabilities
- Ligases
- Long-Term Potentiation
- Mice
- Motor Activity
- Mutation
- Neurons
- Seizures
- Synapses
- Tumor Suppressor Protein p53