Article

Modeling human age-associated increase in Gadd45γ expression leads to spatial recognition memory impairments in young adult mice

2020-01-14

Abstract excerpt

Aging is associated with the progressive decay of cognitive function. Hippocampus-dependent processes, such as the formation of spatial memory, are particularly vulnerable to aging. Currently, the molecular mechanisms responsible for age-dependent cognitive decline are largely unknown. Here, we investigated the expression and function of the growth arrest DNA damage gamma (Gadd45γ) during aging and cognition. We r...

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Literature Corpus work: f0ac6c1b-7cfa-5fab-a0f0-a9b8eb607bb9
DOI: 10.1101/2020.01.12.903112

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