Article
DNA polymerase β deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes.
Nucleic acids research - 1 Jan 2015
Sykora Peter, Misiak Magdalena, Wang Yue, Ghosh Somnath, Leandro Giovana S, Liu Dong, Tian Jane, Baptiste Beverly A, Cong Wei-Na, Brenerman Boris M, Fang Evandro, Becker Kevin G, Hamilton Royce J, Chigurupati Soumya, Zhang Yongqing, Egan Josephine M, Croteau Deborah L, Wilson David M, Mattson Mark P, Bohr Vilhelm A
Abstract excerpt
We explore the role of DNA damage processing in the progression of cognitive decline by creating a new mouse model. The new model is a cross of a common Alzheimer's disease (AD) mouse (3xTgAD), with a mouse that is heterozygous for the critical DNA base excision repair enzyme, DNA polymerase β. A reduction of this enzyme causes neurodegeneration and aggravates the AD features of the 3xTgAD mouse, inducing...
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