Article

Mitochondrial OPA1 deficiency causes reversible defects in adult neurogenesis-associated spatial memory in mice

2021-11-19

Abstract excerpt

Mitochondria are integrative hubs central to cellular adaptive pathways. Such pathways are critical in highly differentiated post-mitotic neurons, the plasticity of which sustains brain function. Consequently, defects in mitochondrial dynamics and quality control appear instrumental in neurodegenerative diseases and may also participate in cognitive impairments. To directly test this hypothesis, we analyzed cognit...

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Literature Corpus work: 8f41aad7-ff29-539f-b12b-14f5d6fb3ab5
DOI: 10.1101/2021.11.16.468792

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