Article

A tetracycline antibiotic minocycline prevents early aging phenotypes in mice heterozygous for RP58

2021-09-20

Abstract excerpt

<h4>Summary</h4> In humans, cognitive and motor functions develop in association with maturation, followed by a decline in advancing age. In this study, we aimed to provide a method for extending healthy lifespan by preventing age-related phenomena. Therefore, we focused on RP58, a transcriptional repressor, whose expression is reduced during aging in the human cortex. In the Rp58 hetero-knockout (KO) mice, obje...

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Literature Corpus work: dd41d886-9de5-5dcd-9b01-996dc225ef25
DOI: 10.1101/2021.09.18.460879

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