PCSK9 SNP rs11591147 is associated with low cholesterol levels but not with cognitive performance or noncardiovascular clinical events in an elderly population.

doi:10.1194/jlr.P033969

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Article

PCSK9 SNP rs11591147 is associated with low cholesterol levels but not with cognitive performance or noncardiovascular clinical events in an elderly population.

Journal of lipid research - 1 Feb 2013

Postmus Iris, Trompet Stella, de Craen Anton J M, Buckley Brendan M, Ford Ian, Stott David J, Sattar Naveed, Slagboom P Eline, Westendorp Rudi G J, Jukema J Wouter

Abstract excerpt

Proprotein convertase subtilisin-like/kexin type 9 (PCSK9) is a protein involved in LDL-cholesterol metabolism. The single-nucleotide polymorphism (SNP) rs11591147 has been associated with lower LDL-cholesterol and a lower risk of coronary heart disease. Because PCSK9 has high affinity to the LDL receptor, inhibiting PCSK9 is a testable therapeutic target for lipid-lowering therapy. Currently, several approaches...

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PMID: 23300213
DOI: 10.1194/jlr.P033969
PMCID: PMC3588880

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PCSK9

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