Article
Genetic variation at the PCSK9 locus moderately lowers low-density lipoprotein cholesterol levels, but does not significantly lower vascular disease risk in an elderly population.
Atherosclerosis - 1 Sept 2008
Polisecki Eliana, Peter Inga, Robertson Michele, McMahon Alex D, Ford Ian, Packard Christopher, Shepherd James, Jukema J Wouter, Blauw Gerard J, Westendorp Rudi G J, de Craen Anton J M, Trompet Stella, Buckley Brendan M, Murphy Michael B, Ordovas Jose M, Schaefer Ernst J
Abstract excerpt
Caucasian carriers of the T allele at R46L in the proprotein convertase subtilisin/kexin type 9 (PCSK9) locus have been reported to have 15% lower low-density lipoprotein (LDL) cholesterol (C) levels and 47% lower coronary heart disease (CHD) risk. Our objective was to examine two PCSK9 single nucleotide polymorphisms (SNPs), R46L and E670G, in 5783 elderly participants in Prospective Study of Pravastatin in the...
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