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Article

Loss-of-Function PCSK9 Mutations Are Not Associated With Alzheimer Disease.

Journal of geriatric psychiatry and neurology - 1 Mar 2018

Paquette Martine, Saavedra Yascara Grisel Luna, Poirier Judes, Théroux Louise, Dea Doris, Baass Alexis, Dufour Robert

Abstract excerpt

BACKGROUND: Hypercholesterolemia is a major risk factor for the late-onset form of Alzheimer disease (AD). Loss-of-function (LOF) mutations of PCSK9 and PCSK9 inhibitors lower low-density lipoprotein cholesterol (LDL-C) and have been associated with a reduced risk of cardiovascular disease. The aim of this study was to examine the effect of PCSK9 LOF variants on risk and age of onset of AD. METHODS: A total of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29562810
DOI: 10.1177/0891988718764330

Genes

PCSK9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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