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Identification of mutations in zebrafish using next-generation sequencing.

Current protocols in molecular biology - 11 Oct 2013

Henke Katrin, Bowen Margot E, Harris Matthew P

Abstract excerpt

Whole-genome sequencing (WGS) has been used in many invertebrate model organisms as an efficient tool for mapping and identification of mutations affecting particular morphological or physiological processes. However, the application of WGS in highly polymorphic, larger genomes of vertebrates has required new experimental and analytical approaches. As a consequence, a wealth of different analytical tools has been...

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PMID: 24510885
DOI: 10.1002/0471142727.mb0713s104

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