Article
Methylation and Inactivation of Estrogen, Progesterone, and Androgen Receptors in Prostate Cancer
6 Mar 2002
Abstract excerpt
BACKGROUND: Prostate cancer development is initially steroid hormone dependent. Estrogen receptors (ERs), androgen receptors (ARs), and progesterone receptors (PRs) have been identified in normal and cancerous prostate tissues. We investigated whether the promoter regions of these steroid receptor genes are methylated and inactivated in prostate cancer cells and tissues. METHODS: The expression and promoter...
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