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Article

Methylation and silencing of the retinoic acid receptor-β2 gene in cervical cancer

21 Mar 2002

Abstract excerpt

BACKGROUND: Expression of the retinoic acid receptor beta2 (RAR-beta2), a putative tumor suppressor gene, is reduced in various human cancers, including squamous cell carcinomas (SCC) of the uterine cervix. The mechanism of the inhibition of RAR-beta2 expression remains obscure. We examined whether methylation of RAR-beta2 gene could be responsible for this silencing in cervical SCC. METHODS: Expression of...

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PMID: 11945179
DOI: 10.1186/1471-2407-2-4

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