Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Insensitivity to Transforming Growth Factor-β Results from Promoter Methylation of Cognate Receptors in Human Prostate Cancer Cells (LNCaP)

19 May 2005

Abstract excerpt

Prostate cancers often develop insensitivity to TGF-beta to gain a growth advantage. In this study, we explored the status of promoter methylation of TGF-beta receptors (TbetaRs) in a prostate cancer cell line, LNCaP, which is insensitive to TGF-beta. Sensitivity to TGF-beta was restored in cells treated with 5-Aza-2'-deoxycytidine (5-Aza), as indicated by an increase in the expression of phosphorylated Smad-2,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Prostate Cancer Treatment and Research
Share to TGF-β signaling in diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15905358
DOI: 10.1210/me.2005-0096

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Insensitivity to Transforming Growth Factor-β Results from Promoter Methylation of Cognate Receptors in Human Prostate Cancer Cells (LNCaP)PMID 15905358Read ↗

TGF-β Regulates DNA Methyltransferase Expression in Prostate Cancer, Correlates with Aggressive Capabilities, and Predicts Disease RecurrenceSemantic proximity Read ↗

Androgenic Control of Transforming Growth Factor-β Signaling in Prostate Epithelial Cells through Transcriptional Suppression of Transforming Growth Factor-β Receptor IISemantic proximity Read ↗

Novel permissive role of epidermal growth factor in transforming growth factor beta (TGF-beta) signaling and growth suppression. Mediation by stabilization of TGF-beta receptor type II.Semantic proximity Read ↗

Methylation and Inactivation of Estrogen, Progesterone, and Androgen Receptors in Prostate CancerSemantic proximity Read ↗

KSHV LANA inhibits TGF-β signaling through epigenetic silencing of the TGF-β type II receptorSemantic proximity Read ↗

CpG hypermethylation of the promoter region inactivates the estrogen receptor-? gene in patients with prostate carcinomaSemantic proximity Read ↗

Transfection of the type I TGF-beta receptor restores TGF-beta responsiveness in pancreatic cancer.Semantic proximity Read ↗

Tumor suppressor activity of the TGF-beta pathway in human cancers.Semantic proximity Read ↗

The presence of RNA polymerase II, active or stalled, predicts epigenetic fate of promoter CpG islands.Semantic proximity Read ↗

Transcriptional regulation of theTGF-β1promoter by androgen receptorSemantic proximity Read ↗

DNA methylation associated with polycomb repression in retinoic acid receptor β silencingSemantic proximity Read ↗

IFN Unresponsiveness in LNCaP Cells Due to the Lack of <i>JAK1</i> Gene ExpressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.