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CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance

2 Feb 2009

Abstract excerpt

Cytotoxic T lymphocyte antigen-4 (CTLA-4) plays a critical role in negatively regulating T cell responses and has also been implicated in the development and function of natural FOXP3(+) regulatory T cells. CTLA-4-deficient mice develop fatal, early onset lymphoproliferative disease. However, chimeric mice containing both CTLA-4-deficient and -sufficient bone marrow (BM)-derived cells do not develop disease,...

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PMID: 19188497
DOI: 10.1084/jem.20081811

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CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerancePMID 19188497Read ↗

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CD8+ T Cell-Mediated Suppression of Autoimmunity in a Murine Lupus Model of Peptide-Induced Immune Tolerance Depends on Foxp3 ExpressionSemantic proximity Read ↗

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CD4⁺ T cells from IPEX patients convert into functional and stable regulatory T cells by FOXP3 gene transfer.Semantic proximity Read ↗

CD8+ Foxp3+ T cells share developmental and phenotypic features with classical CD4+ Foxp3+ regulatory T cells but lack potent suppressive activity.Semantic proximity Read ↗

In vivo overexpression of CTLA-4 suppresses lymphoproliferative diseases and thymic negative selection.Semantic proximity Read ↗

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