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Article

Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling.

The Journal of cell biology - 5 Sept 2011

Berndt Jason D, Aoyagi Atsushi, Yang Peitzu, Anastas Jamie N, Tang Lan, Moon Randall T

Abstract excerpt

Receptor-like tyrosine kinase (RYK) functions as a transmembrane receptor for the Wnt family of secreted protein ligands. Although RYK undergoes endocytosis in response to Wnt, the mechanisms that regulate its internalization and concomitant activation of Wnt signaling are unknown. We discovered that RYK both physically and functionally interacts with the E3 ubiquitin ligase Mindbomb 1 (MIB1). Overexpression of...

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Source

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Identifiers

PMID: 21875946
DOI: 10.1083/jcb.201107021
PMCID: PMC3171123

Genes

RYK
MIB1
CTNNB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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