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Article

Casitas B-lineage lymphoma mutants activate AKT to induce transformation in cooperation with class III receptor tyrosine kinases.

Experimental hematology - 1 Mar 2013

Polzer Harald, Janke Hanna, Schmid Diana, Hiddemann Wolfgang, Spiekermann Karsten

Abstract excerpt

In addition to overexpression and the occurrence of activating mutations, receptors can be aberrantly activated by impaired downregulation. In this study, we show that an oncogenic mutant of the ubiquitin ligase casitas B-lineage lymphoma (CBL; CBLΔexon8), which is found in acute myeloid leukemia patients, predominantly cooperates with receptor tyrosine kinase (RTK) class III receptors (PDGFRA, PDGFRB, KIT, and...

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Source

Identifiers

PMID: 23127761
DOI: 10.1016/j.exphem.2012.10.016

Genes

CBL
FLT3
AKT1
KIT
PDGFRA
PDGFRB

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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