Article
c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor.
Genes & development - 1 Dec 1998
Levkowitz G, Waterman H, Zamir E, Kam Z, Oved S, Langdon W Y, Beguinot L, Geiger B, Yarden Y
Abstract excerpt
Ligand-induced down-regulation of two growth factor receptors, EGF receptor (ErbB-1) and ErbB-3, correlates with differential ability to recruit c-Cbl, whose invertebrate orthologs are negative regulators of ErbB. We report that ligand-induced degradation of internalized ErbB-1, but not ErbB-3, i...
Topics
- Biological Transport
- Cell Compartmentation
- Down-Regulation
- Endocytosis
- Endosomes
- ErbB Receptors
- Ligands
- Models, Biological
- Mutation
- Oncogene Protein v-cbl
- Protein Processing, Post-Translational
- Protein-Tyrosine Kinases
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-cbl