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Article

The A3 allele of the HLA-DQA1 locus is associated with susceptibility to type 1 diabetes in Japanese.

Proceedings of the National Academy of Sciences of the United States of America - 1 Feb 1990

Todd J A, Fukui Y, Kitagawa T, Sasazuki T

Abstract excerpt

Analysis of the frequencies of class II HLA-DR and HLA-DQ alleles by serological and DNA typing in 49 Japanese patients with type 1 (insulin-dependent) diabetes and 31 Japanese controls indicates the following. (i) Susceptibility is more strongly associated with the HLA-DQ subregion than with the HLA-DR subregion. (ii) Of the class II alleles detected, the A3 allele of the DQA1 locus was the most strongly...

Topics

Alleles
Base Sequence
Diabetes Mellitus, Type 1
Disease Susceptibility
Gene Frequency
HLA-DQ Antigens
HLA-DQ beta-Chains
Haplotypes
Humans
Japan
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oligonucleotide Probes

Polymerase Chain Reaction

Reference Values

Source

Open in PubMed Open full text

Identifiers

PMID: 2300572
DOI: 10.1073/pnas.87.3.1094
PMCID: PMC53417

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2300572-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Related research

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The A3 allele of the HLA-DQA1 locus is associated with susceptibility to type 1 diabetes in Japanese.PMID 2300572Read ↗

Genetic analysis of HLA class II alleles and susceptibility to type 1 (insulin-dependent) diabetes mellitus in Japanese subjects.Semantic proximity Read ↗

An investigation of Japanese subjects maps susceptibility to type 1 (insulin-dependent) diabetes mellitus close to the DQA1 gene.Semantic proximity Read ↗

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