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Article

Relationship of VP-16 to the classical multidrug resistance phenotype.

Cancer research - 15 May 1992

Sehested M, Friche E, Jensen P B, Demant E J

Abstract excerpt

The classical multidrug resistance (MDR) phenotype is characterized by cross-resistance between a number of chemically unrelated drugs due to an increased efflux across the plasma membrane via a P-glycoprotein-mediated mechanism. The epipodophyllotoxin derivatives etoposide (VP-16) and teniposide (VM-26) are usually included among the drugs recognized by this MDR phenotype, and the MDR EHR2/DNR cell line is...

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PMID: 1581902

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