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Article

Inhibition of etoposide (VP-16)-induced DNA recombination and mutant frequency by Bcl-2 protein overexpression.

Cancer research - 15 Sept 1995

Hashimoto H, Chatterjee S, Berger N A

Abstract excerpt

Bcl-2 has been shown to inhibit apoptosis induced by several anticancer agents and to cause a dissociation between etoposide (VP-16)-induced protein-cross-linked DNA strand breaks and VP-16-induced cell death. We suggested previously that VP-16-induced cytotoxicity is mediated by a series of events leading from cleavable complex formation to aberrant DNA recombination, as measured by sister chromatid exchange...

Topics

Animals
Cells, Cultured
Cricetinae
DNA
DNA Damage
Etoposide
Hypoxanthine Phosphoribosyltransferase
Mutation
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-bcl-2
Recombination, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sister Chromatid Exchange

Source

Identifiers

PMID: 7664276

Genes

BCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7664276-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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