Article
Enhanced 9-(2-phosphonylmethoxyethyl)adenine secretion by a specific, indomethacin-sensitive efflux pump in a mutant 9-(2-phosphonylmethoxyethyl)adenine-resistant human erythroleukemia K562 cell line.
Molecular pharmacology - 1 Nov 1998
Hatse S, De Clercq E, Balzarini J
Abstract excerpt
We have investigated the molecular basis of the 100-fold resistance of mutant human erythroleukemia K562/PMEA-1 cells to the antiproliferative potential of 9-(2-phosphonylmethoxyethyl)adenine (PMEA). Upon exposure to high PMEA concentrations, comparable intracellular PMEA levels were initially ob...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- ATP-Binding Cassette Transporters
- Adenine
- Adenine Nucleotides
- Animals
- Anti-Inflammatory Agents, Non-Steroidal
- Antimetabolites
- Antiviral Agents
- Biological Transport
- Cycloheximide
- Dactinomycin
- Drug Resistance, Neoplasm
- Extracellular Space
- Flow Cytometry
- Humans
- Immunoblotting
- Indomethacin
- K562 Cells